Mycosafe was originally founded under the name Mycoplasma Testing & Consulting GmbH by Prof. Renate Rosengarten in December 2003 as the first and only contract research organisation in Austria and one of the few in Europe specialising in the GMP-compliant quality control testing for the detection of mycoplasma contamination. Today, Mycosafe is recognised as a leading contract research organisation with a high level of expertise in the area of mycoplasma biosafety of cell cultures, virus stocks and related biopharmaceutical products and vaccines.

Since December 2004, Mycosafe is operating under the new legal name Mycosafe Diagnostics GmbH.